GSK3494245
Cat. No.：YN252298
| 产品名称: | GSK3494245 |
| CAS No.: | 2080410-41-7 |
| Chemical Name: | |
| Synonyms: | DDD01305143 |
| 分子量: | 410.4447 |
| 分子式: | C21H23FN6O2 |
| SMILES: | FC1C([H])=C([H])C(=C([H])C=1C1C([H])=C([H])N2C(N=1)=NC([H])=C2N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H])N([H])C(N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H])=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK3494245 (DDD01305143) 是一种有效的、具有口服活性的、选择性的可在夹在 β4 和 β5 亚基之间的位点结合寄生虫蛋白酶体 (proteasome) 的糜蛋白酶样活性抑制剂(对于 WTL.donovani蛋白酶体IC50=0.16μM)。GSK3494245 适度抑制人蛋白酶体的糜蛋白酶样活性 (IC50: 26S=13 µM；富集的 THP-1 提取物 IC50=40 µM)。GSK3494245 具有良好的生物安全特性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
