TPCK
Cat. No.：YN252385
| 产品名称: | TPCK |
| CAS No.: | 402-71-1 |
| Chemical Name: | L-1-Chloro-3-tosylamidyl-4-phenyl-2-butanone; L-1-Chloro-4-phenyl-3-p-tolylsulfonamidobutan-2-one; L-1-Chloro-4-phenyl-3-toluene-p-sulfonamido-2-butanone; L-1-Tosylamide-2-phenylethylchloromethyl Ketone; L-1-Tosylamido-2-phenylethyl Chloromethyl Ketone; L |
| Synonyms: | L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK |
| 分子量: | 351.85 |
| 分子式: | C17H18ClNO3S |
| SMILES: | 暂无 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | TPCK (L-1-Tosylamido-2-phenylethyl chloromethyl ketone; L-TPCK) 是一种有效的丝氨酸蛋白酶抑制剂，可与 HPV-18 E7 蛋白的视网膜母细胞瘤蛋白 (RB) 结合核心发生反应并消除其 RB 结合能力。TPCK 在添加到培养基后能够修饰活角质形成细胞中的 E7 蛋白。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Jitkaew, S. et al.: J. Bio. Chem., 284, 27827 (2009)
Kim, K. et al.: Biochem. Biophys. Res. Comm., 306, 954 (2003)
Griscavage, J. et al.: Biochem. Biophys. Res. Comm., 215, 721 (1995)
