Methotrexate α-tert-butyl ester
Cat. No.：YN290255
| 产品名称: | Methotrexate α-tert-butyl ester |
| CAS No.: | 79640-70-3 |
| Chemical Name: | N-[4-[[(2,4-Diamino-6-pteridinyl)methyl]methylamino]benzoyl]-L-glutamic Acid 1-(1,1-Dimethylethyl) Ester |
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| 分子量: | 510.55 |
| 分子式: | C₂₄H₃₀N₈O₅ |
| SMILES: | O=C(O)CC[C@H](NC(C1=CC=C(N(CC2=NC3=C(N)N=C(N)N=C3N=C2)C)C=C1)=O)C(OC(C)(C)C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Methotrexate α-tert-butyl ester，经 OtBu 修饰，显著降低 HT1080 荷瘤小鼠的肿瘤生长。Methotrexate 是一种抗代谢和抗叶叶酸剂，也是一种免疫抑制剂和抗肿瘤药物。 |
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Yoshii, T., et al.: J. Am. Chem. Soc., 136, 16635 (2014)
