Aminopterin
Cat. No.：YN290304
CAS No. ：54-62-6
| 产品名称: | Aminopterin |
| CAS No.: | 54-62-6 |
| Chemical Name: | N-[4-[[(2,4-diamino-6-pteridinyl)methyl]amino]benzoyl]-L-glutamic acid |
| Synonyms: | 氨基蝶呤; 4-Aminofolic acid; APGA |
| 分子量: | 440.41 |
| 分子式: | C₁₉H₂₀N₈O₅ |
| SMILES: | NC1=NC(N)=C2C(N=CC(CNC3=CC=C(C(N[C@@H](CCC(O)=O)C(O)=O)=O)C=C3)=N2)=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aminopterin (4-Aminofolic acid)，叶酸的 4-氨基衍生物，是叶酸 (folic acid) 拮抗剂。Aminopterin 催化叶酸还原为四氢叶酸，Aminopterin 竞争性抑制二氢叶酸还原酶(DHFR)，Ki值为 3.7 pM。Aminopterin 具有抗癌和免疫抑制活性。Aminopterin 用于研究儿童白血病。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Farber, S., Diamond, L.K., Mercer, R.D., et al.Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acidN. Engl. J. Med.238(23),787-793(1948)
Goldin, A., Venditti, J.M., Humphreys, S.R., et al.A quantitative comparison of the antileukemic effectiveness of two folic acid antagonists in miceJ. Natl. Cancer Inst.15(6),1657-1664(1955)
Cole, P.D., Drachtman, R.A., Smith, A.K., et al.Phase II trial of oral aminopterin for adults and children with refractory acute leukemiaClin. Cancer Res.11(22),8089-8096(2005)
Littlefield, J.W.Selection of hybrids from matings of fibroblasts in vitro and their presumed recombinantsScience145(3633),709-710(1964)
