SNS-032
Cat. No.：YN270003
CAS No. ：345627-80-7
| 产品名称: | SNS-032 |
| CAS No.: | 345627-80-7 |
| Chemical Name: | N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4-piperidinecarboxamide |
| Synonyms: | BMS-387032 |
| 分子量: | 380.53 |
| 分子式: | C₁₇H₂₄N₄O₂S₂ |
| SMILES: | CC(C)(C1=CN=C(CSC2=CN=C(NC(C3CCNCC3)=O)S2)O1)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SNS-032 (BMS-387032) 是一种有效的，选择性的CDK2/7/9抑制剂，IC50值分别为 48 nM/62 nM/4 nM。SNS-032 具有抗肿瘤的功效。 |
| IC50和靶点: | [{name:"CDK9:4 nM (IC50)"},{name: "CDK2:38 nM (IC50)"},{name: "CDK7:62 nM (IC50)"},{name: "CDK1:480 nM (IC50)"},{name: "CDK4:925 nM (IC50)"}] |
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Misra, R.N., Xiao, H.Y., Kim, K.S., et al.N-(cycloalkylamino)acyl-2-aminothiazole inhibitors of cyclin-dependent kinase 2. N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-4- piperidinecarboxamide (BMS-387032), a highly efficacious and selective antitumor agentJ. Med. Chem.47(7),1719-1728(2004)
Conroy, A., Stockett, D.E., Walker, D., et al.SNS-032 is a potent and selective CDK 2, 7 and 9 inhibitor that drives target modulation in patient samplesCancer Chemother. Pharmacol.64,723-732(2009)
Chen, R., Wierda, W.G., Chubb, S., et al.Mechanism of action of SNS032, a novel cyclindependent kinase inhibitor, in chronic lymphocytic leukemiaBlood113(19),4637-4645(2009)
