(S)-Crizotinib
Cat. No.：YN270011
CAS No. ：1374356-45-2
| 产品名称: | (S)-Crizotinib |
| CAS No.: | 1374356-45-2 |
| Chemical Name: | 3-[(1S)-1-(2,6-dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine |
| Synonyms: | ent-crizotinib |
| 分子量: | 450.34 |
| 分子式: | C₂₁H₂₂Cl₂FN₅O |
| SMILES: | NC1=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@H](C4=C(Cl)C=CC(F)=C4Cl)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-Crizotinib 是一种有效的选择性MTH1(mutT 同源物)抑制剂，IC50为 330 nM。(S)-Crizotinib 通过抑制 MTH1 破坏核苷酸库的稳态，诱导 DNA 单链断裂的增加，激活人结肠癌细胞的 DNA 修复，并有效抑制动物模型中的肿瘤生长。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Huber, K.V.M., Salah, E., Radic, B., et al.Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategyNature508(7495),222-227(2014)
Ji, J., Chen, W., Lian, W., et al.(S)-crizotinib reduces gastric cancer growth through oxidative DNA damage and triggers pro-survival akt signalCell Death Dis.9(6),660(2018)
