Ubiquitin Isopeptidase Inhibitor I, G5
Cat. No.：YN270016
CAS No. ：108477-18-5
| 产品名称: | Ubiquitin Isopeptidase Inhibitor I, G5 |
| CAS No.: | 108477-18-5 |
| Chemical Name: | tetrahydro-3,5-bis[(4-nitrophenyl)methylene]-4H-thiopyran-4-one, 1,1-dioxide |
| Synonyms: | NSC144303 |
| 分子量: | 414.39 |
| 分子式: | C₁₉H₁₄N₂O₇S |
| SMILES: | O=C(/C(C1)=C/C2=CC=C([N+]([O-])=O)C=C2)/C(CS1(=O)=O)=C/C3=CC=C([N+]([O-])=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ubiquitin Isopeptidase Inhibitor I, G5 (NSC 144303)是凋亡不依赖的半胱天冬酶和细胞凋亡的激活剂，对E1A和E1A/C9DN细胞的IC50值分别为1.76和1.6 μM。 |
| IC50和靶点: | |
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Aleo, E., Henderson, C.J., Fontanini, A., et al.Identification of new compounds that trigger apoptosome-independent caspase activation and apoptosisCancer Res.66(18),9235-9244(2006)
Fontanini, A., Foti, C., Potu, H., et al.The isopeptidase inhibitor G5 triggers a caspase-independent necrotic death in cells resistant to apoptosis: A comparative study with the proteasome inhibitor bortezomibJ. Biol. Chem.284(13),8369-8381(2009)
