WT-161
Cat. No.：YN270020
CAS No. ：1206731-57-8
| 产品名称: | WT-161 |
| CAS No.: | 1206731-57-8 |
| Chemical Name: | 8-(hydroxyamino)-8-oxo-octanoic acid, 2-[[4-(diphenylamino)phenyl]methylene]hydrazide |
| Synonyms: | WT161; WT 161 |
| 分子量: | 458.55 |
| 分子式: | C₂₇H₃₀N₄O₃ |
| SMILES: | O=C(N/N=C/C1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1)CCCCCCC(NO)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | WT-161是有效选择性的HDAC6抑制剂，IC50值为0.40 nM。 |
| IC50和靶点: | [{name:"HDAC6:0.4 nM (IC50)"},{name: "HDAC1:8.35 nM (IC50)"},{name: "HDAC2:15.4 nM (IC50)"},{name: "HDAC3:51.6 nM (IC50)"},{name: "HDAC8:1430 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Hideshima, T., Qi, J., Paranal, R.M., et al.Discovery of selective small-molecule HDAC6 inhibitor for overcoming proteasome inhibitor resistance in multiple myelomaProc. Natl. Acad. Sci. USA,201608067(2016)
