Monastrol
Cat. No.：YN270026
CAS No. ：329689-23-8
| 产品名称: | Monastrol |
| CAS No.: | 329689-23-8 |
| Chemical Name: | 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-methyl-2-thioxo-5-pyrimidinecarboxylic acid, ethyl ester |
| Synonyms: | (±)-Monastrol |
| 分子量: | 292.35 |
| 分子式: | C₁₄H₁₆N₂O₃S |
| SMILES: | O=C(C1=C(C)NC(NC1C2=CC=CC(O)=C2)=S)OCC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Monastrol是具有高效性和细胞渗透性的有丝分裂驱动蛋白Eg5的抑制剂，IC50值为 14 μM。 |
| IC50和靶点: | [{name:"Eg5:14 μM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Mayer, T.U., Kapoor, T.M., Haggarty, S.J., et al.Small molecule inhibitor of mitotic spindle bipolarity identified in a phenotype-based screenScience286,971-974(1999)
Klein, E., DeBonis, S., Thiede, B., et al.New chemical tools for investigating human mitotic kinesin Eg5Bioorg. Med. Chem.15(19),6474-6488(2007)
Kapoor, T.M., Mayer, T.U., Coughlin, M.L., et al.Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin Eg5J. Cell Biol.150(5),975-988(2000)
Good, J.A.D., Skoufias, D.A., and Kozielski, F.Elucidating the functionality of kinesins: An overview of small molecule inhibitorsSemin. Cell Dev. Biol.22(9),935-945(2011)
