Importazole
Cat. No.：YN270027
CAS No. ：662163-81-7
| 产品名称: | Importazole |
| CAS No.: | 662163-81-7 |
| Chemical Name: | N-(1-phenylethyl)-2-(1-pyrrolidinyl)-4-quinazolinamine |
| Synonyms: | 4-Quinazolinamine, N-(1-phenylethyl)-2-(1-pyrrolidinyl)-;Importazole;N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-aMine |
| 分子量: | 318.42 |
| 分子式: | C₂₀H₂₂N₄ |
| SMILES: | CC(NC1=C2C=CC=CC2=NC(N3CCCC3)=N1)C4=CC=CC=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Importazole是核转运受体importin-β的小分子抑制剂。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Soderholm, J.F., Bird, S.L., Kalab, P., et al.Importazole, a small molecule inhibitor of the transport receptor importin-βACS Chem Biol.6(7),700-708(2011)
Bai, L., Michael, W.M., and Yan, S.Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extractsCell. Signal.26(5),857-867(2015)
Yan, W.Q., Du, J., Jiang, H., et al.Effect of nuclear receptor inhibitor importazole on the proliferation and apoptosis of multiple myeloma cellsZhonghua Xue Ye Xue Za Zhi34(4),323-326(2013)
Bird, S.L., and Weis, K.RanGTP and CLASP1 cooperate to position the mitotic spindleMol. Biol. Cell24(16),2506-2514(2013)
