ZM-447439
Cat. No.：YN270029
CAS No. ：331771-20-1
| 产品名称: | ZM-447439 |
| CAS No.: | 331771-20-1 |
| Chemical Name: | N-[4-[[6-methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]-benzamide |
| Synonyms: | ZM 447439 |
| 分子量: | 513.59 |
| 分子式: | C₂₉H₃₁N₅O₄ |
| SMILES: | O=C(NC1=CC=C(NC2=C(C(C=C3OCCCN4CCOCC4)=NC=N2)C=C3OC)C=C1)C5=CC=CC=C5 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ZM-447439是极光激酶 (aurora) 抑制剂，对aurora A和B的IC50值分别为110和130 nM。 |
| IC50和靶点: | [{name:"Aurora A:110 nM (IC50)"},{name: "Aurora B:130 nM (IC50)"}] |
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| Clinical Trial: | |
| Solvent & Solubility: |
Carmena, M., Ruchaud, S., and Earnshaw, W.C.Making the Auroras glow: Regulation of Aurora A and B kinase function by interacting proteinsCurr. Opin. Cell Biol.21(6),796-805(2009)
Girdler, F., Gascoigne, K.E., Eyers, P.A., et al.Validating Aurora B as an anti-cancer drug targetJ. Cell Sci.119(Pt 17),3664-3675(2006)
Ditchfield, C., Johnson, V.L., Tighe, A., et al.Aurora B couples chromosome alignment with anaphase by targeting BubR1, Mad2, and Cenp-E to kinetochoresJ. Cell Biol.161(2),267-280(2003)
Gadea, B.B., and Ruderman, J.V.Aurora kinase inhibitor ZM447439 blocks chromosome-induced spindle assembly, the completion of chromosome condensation, and the establishment of the spindle integrity checkpoint in Xenopus egg extractsMol. Biol. Cell16(3),1305-1318(2005)
