Ixabepilone
Cat. No.：YN270043
| 产品名称: | Ixabepilone |
| CAS No.: | 219989-84-1 |
| Chemical Name: | (1S,3S,7S,10R,11S,12S,16R)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-17-oxa-4-azabicyclo[14.1.0]heptadecane-5,9-dione |
| Synonyms: | 伊沙匹隆; BMS-247550; Aza-epothilone B |
| 分子量: | 506.70 |
| 分子式: | C₂₇H₄₂N₂O₅S |
| SMILES: | O=C([C@@H]([C@H]([C@H](CCC[C@]1(O[C@]1(C[C@H](N2)/C(C)=C/C3=CSC(C)=N3)[H])C)C)O)C)C(C)([C@H](CC2=O)O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ixabepilone (BMS-247550) 是一种可口服的microtubule抑制剂，能够与微管蛋白结合，促进微管蛋白的聚合和微管的稳定，因此使细胞停滞在 G2-M 期，诱导细胞凋亡。 |
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Lee, F.Y., Borzilleri, R., Fairchild, C.R., et al.BMS-247550: A novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacyClin. Cancer Res.7(5),1429-1437(2001)
Peterson, J.K., Tucker, C., Favours, E., et al.In vivo evaluation of ixabepilone (BMS247550), a novel epothilone B derivative, against pediatric cancer modelsClin. Cancer Res.11(19 Pt 1),6950-6958(2005)
Cheng, K.L., Bradley, T., and Budman, D.R.Novel microtubule-targeting agents - the epothilonesBiologics2(4),789-811(2008)
