GSK-923295
Cat. No.：YN270044
CAS No. ：1088965-37-0
| 产品名称: | GSK-923295 |
| CAS No.: | 1088965-37-0 |
| Chemical Name: | 3-chloro-N-[(1S)-2-[[2-(dimethylamino)acetyl]amino]-1-[[4-[8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl]phenyl]methyl]ethyl]-4-(1-methylethoxy)-benzamide |
| Synonyms: | GSK923295,GSK-923295,GSK923295 |
| 分子量: | 592.13 |
| 分子式: | C₃₂H₃₈ClN₅O₄ |
| SMILES: | O=C(N[C@@H](CC1=CC=C(C2=CN3C(C([C@@H](O)C)=CC=C3)=N2)C=C1)CNC(CN(C)C)=O)C4=CC(Cl)=C(C=C4)OC(C)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK-923295 是一种特异性的变构着丝粒相关蛋白-E(CENP-E)驱动蛋白 ATPase 活性抑制剂，作用于人类和犬类此酶，Ki分别为 3.2±0.2 nM 和 1.6±0.1 nM。 |
| IC50和靶点: | [{name:"CENP-E:1.6 nM (Ki, Canine CENP-E)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Wood, K.W., Lad, L., Luo, L., et al.Antitumor activity of an allosteric inhibitor of centromere-associated protein-EProc. Natl. Acad. Sci. USA107(13),5839-5844(2010)
Qian, X., McDonald, A., Zhou, H.-J., et al.Discovery of the first potent and selective inhibitor of centromere-associated protein E: GSK923295ACS Med. Chem. Lett.1(1),30-34(2010)
Bennett, A., Bechi, B., Tighe, A., et al.Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidyOncotarget6(25),20921-20932(2015)
