CITCO
Cat. No.：YN270050
CAS No. ：338404-52-7
| 产品名称: | CITCO |
| CAS No.: | 338404-52-7 |
| Chemical Name: | O-[(3,4-dichlorophenyl)methyl]oxime 6-(4-chlorophenyl)-imidazo[2,1-b]thiazole-5-carboxaldehyde |
| Synonyms: | CITCO |
| 分子量: | 436.74 |
| 分子式: | C₁₉H₁₂Cl₃N₃OS |
| SMILES: | ClC1=CC=C(C2=C(/C=N/OCC3=CC=C(Cl)C(Cl)=C3)N4C(SC=C4)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | CITCO 是一种组成型雄甾烷 (Constitutive androstane) 受体激动剂，抑制脑肿瘤干细胞 (BTSCs) 的生长和扩增。CITCO 是一种咪唑并噻唑衍生物，其作为人CAR的选择性激动剂起作用。CITCO 对于孕烷 X 受体 (PXR)的 EC50为 49 nM，并且对其他核受体没有活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Maglich, J.M., Parks, D.J., Moore, L.B., et al.Identification of a novel human constitutive androstane receptor (CAR) agonist and its use in the identification of CAR target genesJ. Biol. Chem.278(19),17277-17283(2003)
Timsit, Y.E., and Negishi, M.CAR and PXR: The xenobiotic-sensing receptorsSteroids72(3),231-246(2007)
Jinno, H., Tanaka-Kagawa, T., Hanioka, N., et al.Identification of novel alternative splice variants of human constitutive androstane receptor and characterization of their expression in the liverMol. Pharmacol.65(3),496-502(2004)
Kanno, Y., Tanuma, N., Yatsu, T., et al.Nigramide J is a novel potent inverse agonist of the human constitutive androstane receptorPharmacol. Res. Perspect.2(1),2(2014)
Chen, T., Laurenzana, E.M., Coslo, D.M., et al.Proteasomal interaction as a critical activity modulator of the human constitutive androstane receptorBiochem. J.458(1),95-107(2014)
