Pralatrexate
Cat. No.：YN270061
CAS No. ：146464-95-1
| 产品名称: | Pralatrexate |
| CAS No.: | 146464-95-1 |
| Chemical Name: | N-[4-[1-[(2,4-diamino-6-pteridinyl)methyl]-3-butyn-1-yl]benzoyl]-L-glutamic acid |
| Synonyms: | 普拉曲沙 |
| 分子量: | 477.47 |
| 分子式: | C₂₃H₂₃N₇O₅ |
| SMILES: | O=C(CC[C@H](NC(C1=CC=C(C=C1)C(CC#C)CC2=NC3=C(N=C(N=C3N=C2)N)N)=O)C(O)=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Pralatrexate 是一种抗叶酸剂，也是一种有效的二氢叶酸还原酶 (DHFR) 抑制剂，Ki值为 13.4 pM。Pralatrexate 是叶酰聚谷氨酸合成酶的底物，具有改善的细胞摄取和保留能力。Pralatrexate 具有抗肿瘤活性，并可用于复发/难治性 T 细胞淋巴瘤的研究。 |
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Sirotnak, F.M., DeGraw, J.I., Colwell, W.T., et al.A new analogue of 10-deazaaminopterin with markedly enhanced curative effects against human tumor xenografts in miceCancer Chemother. Pharmacol.42(4),313-318(1998)
Jain, S., Jirau-Serrano, X., Zullo, K.M., et al.Preclinical pharmacologic evaluation of pralatrexate and romidepsin confirms potent synergy of the combination in a murine model of human T-cell lymphomaClin. Cancer Res.21(9),2096-2106(2015)
Visentin, M., Unal, E.S., Zhao, R., et al.The membrane transport and polyglutamation of pralatrexate, a new-generation dihydrofolate reductase inhibitorCancer Chemother. Pharmacol.72(3),597-606(2013)
Izbicka, E., Diaz, A., Streeper, R., et al.Distinct mechanistic activity profile of pralatrexate in comparison to other antifolates in in vitro and in vivo models of human cancersCancer Chemother. Pharmacol.64(5),993-999(2009)
