Voreloxin
Cat. No.：YN270064
| 产品名称: | Voreloxin |
| CAS No.: | 175414-77-4 |
| Chemical Name: | 1,4-dihydro-7-[(3S,4S)-3-methoxy-4-(methylamino)-1-pyrrolidinyl]-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid |
| Synonyms: | SNS-595; Vosaroxin; AG 7352 |
| 分子量: | 401.44 |
| 分子式: | C₁₈H₁₉N₅O₄S |
| SMILES: | O=C(C1=CN(C2=NC=CS2)C3=C(C=CC(N4C[C@H](OC)[C@@H](NC)C4)=N3)C1=O)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Voreloxin (SNS-595; Vosaroxin; AG 7352) 是一种新创的拓扑异构酶 II (topoisomerase II) 抑制剂，能够诱导 DNA 双链断裂，阻滞 G2 期，最终细胞凋亡。 |
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Tsuzuki, Y., Tomita, K., Shibamori, K.-i., et al.Synthesis and structure-activity relationships of novel 7-substituted 1,4-dihydro-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acids as antitumor agents. Part 2J. Med. Chem.47(8),2097-2109(2004)
Hawtin, R.E., Stockett, D.E., Byl, J.A.W., et al.Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase IIPLoS One5(4),e10186(2010)
Hoch, U., Lynch, J., Sato, Y., et al.Voreloxin, formerly SNS-595, has potent activity against a broad panel of cancer cell lines and in vivo tumor modelsCancer Chemother. Pharmacol.64(1),53-65(2009)
