Evofosfamide
Cat. No.：YN270065
CAS No. ：918633-87-1
| 产品名称: | Evofosfamide |
| CAS No.: | 918633-87-1 |
| Chemical Name: | N,N'-bis(2-bromoethyl)-phosphorodiamidic acid, (1-methyl-2-nitro-1H-imidazol-5-yl)methyl ester |
| Synonyms: | TH-302 |
| 分子量: | 449.04 |
| 分子式: | C₉H₁₆Br₂N₅O₄P |
| SMILES: | O=P(NCCBr)(OCC1=CN=C(N1C)[N+]([O-])=O)NCCBr |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Evofosfamide (TH-302) 是一种缺氧 (hypoxia) 激活前药，缺氧 (N2) 和常氧 (21% O2) 环境下，IC50分别为 10 μM 和 1000 μM。 |
| IC50和靶点: | |
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Duan, J.-X., Jiao, H., Kaizerman, J., et al.Potent and highly selective hypoxia-activated achiral phosphoramidate mustards as anticancer drugsJ. Med. Chem.51(8),2412-2420(2008)
Sun, J.D., Liu, Q., Wang, J., et al.Selective tumor hypoxia targeting by hypoxia-activated prodrug TH-302 inhibits tumor growth in preclinical models of cancerClin. Cancer Res.18(3),758-770(2012)
