LAT1-IN-1
Cat. No.：YN270082
| 产品名称: | LAT1-IN-1 |
| CAS No.: | 20448-79-7 |
| Chemical Name: | 2-amino-bicyclo[2.2.1]heptane-2-carboxylic acid |
| Synonyms: | BCH |
| 分子量: | 155.19 |
| 分子式: | C₈H₁₃NO₂ |
| SMILES: | O=C(C1(N)C(C2)CCC2C1)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LAT1-IN-1 (BCH) 是 L 型氨基酸转运蛋白 1(LAT1)的选择性竞争性抑制剂，可显著抑制细胞对氨基酸的摄取和mTOR磷酸化，从而抑制癌细胞生长并诱导细胞凋亡。 |
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Dann, S.G., Selvaraj, A., and Thomas, G.mTOR Complex1-S6K1 signaling: At the crossroads of obesity, diabetes and cancerTrends Mol. Med.13(6),252-259(2007)
Fraga, S., Serrao, M.P., and Soares-Da-Silva, P.L-type amino acid transporters in two intestinal epithelial cell lines function as exchangers with neutral amino acidsJ. Nutr.132(4),733-738(2002)
Kim, D.K., Kanai, Y., Choi, H.W., et al.Characterization of the system L amino acid transporter in T24 human bladder carcinoma cellsBiochim. Biophys. Acta1565(1),112-121(2002)
Kageyama, T., Nakamura, M., Matsuo, A., et al.The 4F2hc/LAT1 complex transports L-DOPA across the blood-brain barrierBrain Res.879(1-2),115-121(2000)
