LRRK2-IN-1
Cat. No.：YN270087
CAS No. ：1234480-84-2
| 产品名称: | LRRK2-IN-1 |
| CAS No.: | 1234480-84-2 |
| Chemical Name: | 5,11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)- 1-piperidinyl]carbonyl] phenyl]amino]- 5,11-dimethyl-6H-pyrimido[4,5-b][1,4] benzodiazepin-6-one |
| Synonyms: | 5,11-二氢-2-[[2-甲氧基-4-[[4-(4-甲基-1-哌嗪基)-1-哌啶基]羰基]苯基]氨基]-5,11-二甲基-6H-嘧啶并[4,5-B][1,4]苯并二氮杂卓-6-酮 |
| 分子量: | 570.69 |
| 分子式: | C₃₁H₃₈N₈O₃ |
| SMILES: | O=C(C1=CC(OC)=C(NC2=NC=C3C(N(C4=C(C(N3C)=O)C=CC=C4)C)=N2)C=C1)N5CCC(CC5)N6CCN(CC6)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | LRRK2-IN-1 是一种有效的，选择性的LRRK2抑制剂，作用于 LRRK2 (G2019S) 和 LRRK2 (WT)，IC50值分别为 6 nM 和 13 nM。 |
| IC50和靶点: | |
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Deng, X., Dzamko, N., Prescott, A., et al.Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2Nat. Chem. Biol.7(4),203-205(2011)
Zhao, J., Molitor, T.P., Langston, J.W., et al.LRRK2 dephosphorylation increases its ubiquitinationBiochem. J.469,107-120(2015)
Manzoni, C., Mamais, A., Dihanich, S., et al.Inhibition of LRRK2 kinase activity stimulates macroautophagyBiochem. Biophys. Acta1833,2900-2910(2013)
