Alisertib
Cat. No.：YN270091
CAS No. ：1028486-01-2
| 产品名称: | Alisertib |
| CAS No.: | 1028486-01-2 |
| Chemical Name: | 4-[[9-chloro-7-(2-fluoro-6-methoxyphenyl)-5H-pyrimido[5,4-d][2]benzazepin-2-yl]amino]-2-methoxy-benzoic acid |
| Synonyms: | MLN 8237 |
| 分子量: | 518.92 |
| 分子式: | C₂₇H₂₀ClFN₄O₄ |
| SMILES: | O=C(C1=CC=C(C=C1OC)NC2=NC=C3CN=C(C4=CC(Cl)=CC=C4C3=N2)C5=C(C=CC=C5F)OC)O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Aliertib (MLN 8237) 是一种口服活性和选择性的Aurora A激酶抑制剂 (IC50=1.2 nM)，与Aurora A 激酶结合，导致有丝分裂纺锤体异常、有丝分裂累积。Aliertib (MLN 8237) 通过靶向白血病细胞中的AKT/mTOR/AMPK/p38途径诱导其凋亡和自噬。具有抗肿瘤活性。 |
| IC50和靶点: | [{name:"Aurora A:1.2 nM (IC50)"},{name: "Aurora B:396.5 nM (IC50)"}] |
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Sells, T.B., Chau, R., Ecsedy, J.A., et al.MLN8054 and alisertib (MLN8237): Discovery of selective oral Aurora A inhibitorsACS Med. Chem. Lett.6(6),630-634(2015)
Manfredi, M.G., Ecsedy, J.A., Chakravarty, A., et al.Characterization of alisertib (MLN8237), an investigational small-molecule inhibitor of Aurora A kinase using novel in vivo pharmacodynamic assaysClin. Cancer Res.17(24),7614-7624(2011)
