ONC212
Cat. No.：YN270097
CAS No. ：1807861-48-8
| 产品名称: | ONC212 |
| CAS No.: | 1807861-48-8 |
| Chemical Name: | 2,4,6,7,8,9-hexahydro-7-(phenylmethyl)-4-[[4-(trifluoromethyl)phenyl]methyl]-imidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1H)-one |
| Synonyms: | ONC 212,ONC-212,ONC212,1807861-48-8 |
| 分子量: | 440.46 |
| 分子式: | C₂₄H₂₃F₃N₄O |
| SMILES: | O=C1N(CC2=CC=C(C(F)(F)F)C=C2)C3=NCCN3C4=C1CN(CC5=CC=CC=C5)CC4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | ONC212 是一种氟化的 ONC201 类似物，是一种有前景的抗癌剂，也是GPR132的选择性激动剂。ONC212 还诱导凋亡 (apoptosis)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Prabhu, V.V., Madhukar, N., Tarapore, R., et al.Abstract 1155: Potent anti-cancer effects of selective GPR132/G2A agonist imipridone ONC212 in leukemia and lymphomaCancer Res.77(13),(2017)
Wagner, J., Kline, C.L., Ralff, M.D., et al.Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212Cell Cycle16(19),1790-1799(2017)
