INCB-057643
Cat. No.：YN270101
CAS No. ：1820889-23-3
| 产品名称: | INCB-057643 |
| CAS No.: | 1820889-23-3 |
| Chemical Name: | 8-(6,7-dihydro-6-methyl-7-oxo-1H-pyrrolo[2,3-c]pyridin-4-yl)-2,2,4-trimethyl-6-(methylsulfonyl)-2H-1,4-benzoxazin-3(4H)-one |
| Synonyms: | |
| 分子量: | 415.46 |
| 分子式: | C₂₀H₂₁N₃O₅S |
| SMILES: | O=C1C(C)(C)OC2=C(C3=CN(C)C(C4=C3C=CN4)=O)C=C(S(=O)(C)=O)C=C2N1C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | INCB-057643 是一种新型，口服生物可利用的BET抑制剂。 |
| IC50和靶点: | |
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Stubbs, M.C., Maduskuie, T., Burn, T., et al.Abstract 5071: Preclinical characterization of the potent and selective BET inhibitor INCB057643 in models of hematologic malignanciesAACR Cancer Res.77(13),5071(2017)
Vázquez, R., Civenni, G., Zoppi, G., et al.Abstract 5793: Anti-tumor efficacy of INCB057643, a novel BET bromodomain inhibitor, in castration-resistant prostate cancer as single agent and in combination therapyAACR Cancer Res.78(13Supp),5793-5793(2018)
