IACS-10759
Cat. No.：YN270109
CAS No. ：1570496-34-2
| 产品名称: | IACS-10759 |
| CAS No.: | 1570496-34-2 |
| Chemical Name: | 4-(methylsulfonyl)-1-[3-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-1,2,4-triazol-1-yl]methyl]phenyl]-piperidine |
| Synonyms: | IACS-10759,IACS10759,IACS 10759 |
| 分子量: | 562.56 |
| 分子式: | C₂₅H₂₅F₃N₆O₄S |
| SMILES: | FC(F)(F)OC1=CC=C(C2=NOC(C3=NN(CC4=CC(N5CCC(S(=O)(C)=O)CC5)=CC=C4)C(C)=N3)=N2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | IACS-10759是氧化磷酸化 (OXPHOS) 复合物I的有效抑制剂。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Molina, J.R., Sun, Y., Protopopova, M., et al.An inhibitor of oxidative phosphorylation exploits cancer vulnerabilityNat. Med.24(7),1036-1046(2018)
Vangapandu, H.V., Alston, B., Morse, J., et al.Biological and metabolic effects of IACS-010759, an OxPhos inhibitor, on chronic lymphocytic leukemia cellsOncotarget9(38),24980-24991(2018)
