Volasertib
Cat. No.：YN270145
CAS No. ：755038-65-4
| 产品名称: | Volasertib |
| CAS No.: | 755038-65-4 |
| Chemical Name: | N-[trans-4-[4-(cyclopropylmethyl)-1-piperazinyl]cyclohexyl]-4-[[(7R)-7-ethyl-5,6,7,8-tetrahydro-5-methyl-8-(1-methylethyl)-6-oxo-2-pteridinyl]amino]-3-methoxy-benzamide |
| Synonyms: | 伏拉塞替; BI 6727 |
| 分子量: | 618.81 |
| 分子式: | C₃₄H₅₀N₈O₃ |
| SMILES: | O=C(C1=CC=C(C(OC)=C1)NC2=NC=C(N(C3=O)C)C(N([C@@H]3CC)C(C)C)=N2)N[C@H]4CC[C@@H](CC4)N5CCN(CC5)CC6CC6 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Volasertib 是一种高效的Polo-like 激酶 1 (PLK1)抑制剂，IC50值为 0.87 nM，同时能够抑制PLK2和PLK3，IC50值分别为 5 和 56 nM。 |
| IC50和靶点: | [{name:"PLK1:0.87 nM (IC50)"},{name: "PLK2:5 nM (IC50)"},{name: "PLK3:56 nM (IC50)"}] |
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| Solvent & Solubility: |
Schöffski, P.Polo-like kinase (PLK) inhibitors in preclinical and early clinical development in oncologyOncologist14(6),559-570(2009)
Rudolph, D., Steegmaier, M., Hoffmann, M., et al.BI 6727, a Polo-like kinase inhibitor with improved pharmacokinetic profile and broad antitumor activityClin. Cancer Res.15(9),3094-3102(2009)
To, K.K.W., Poon, D.C., Chen, X.G., et al.Volasertib (BI 6727), a novel polo-like kinase inhibitor reverses ABCB1 and ABCG2-mediated multidrug resistance in cancer cellsJ.Cancer Ther.Res.2(13),1-10(2015)
