PFK-158
Cat. No.：YN270150
CAS No. ：1462249-75-7
| 产品名称: | PFK-158 |
| CAS No.: | 1462249-75-7 |
| Chemical Name: | 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2E-quinolinyl]-2-propen-1-one |
| Synonyms: | PFK-158,PFK 158 |
| 分子量: | 328.29 |
| 分子式: | C₁₈H₁₁F₃N₂O |
| SMILES: | O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PFK-158 是一种有效的，选择性的PFKFB3抑制剂，IC50值为 137 nM。PFK-158 可减少癌细胞中葡萄糖的摄取，ATP 的产生，乳酸的释放，并诱导细胞凋亡和自噬。PFK-158 具有广泛的抗肿瘤活性。PFK-158 还可以增强 Colistin 对细菌的抵抗力。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Chand, P., and Tapolsky, G.H.Pfkfb3 inhibitor and methods of use as an anti-cancer therapeuticPCT/US2013/031159,(2013)
Chesney, J., Telang, S., and Yaddanapudi, K.Combinations of pfkfb3 inhibitors and immune checkpoint inhibitors to treat cancerPCT/US2016/034590,(2016)
