Fusicoccin
Cat. No.：YN270157
CAS No. ：20108-30-9
| 产品名称: | Fusicoccin |
| CAS No.: | 20108-30-9 |
| Chemical Name: | (1S,4R,5R,6R,6aS,9S,10aR)-3-[(1S)-2-(acetyloxy)-1-methylethyl]-1,2,4,5,6,6a,7,8,9,10a-decahydro-1,5-dihydroxy-9-(methoxymethyl)-6,10a-dimethyldicyclopenta[a,d]cycloocten-4-yl 6-O-(1,1-dimethyl-2-propen-1-yl)-α-D-glucopyranoside, 3-acetate |
| Synonyms: | Fusicoccin;FC-A |
| 分子量: | 680.82 |
| 分子式: | C₃₆H₅₆O₁₂ |
| SMILES: | C[C@](/C=C([C@H]1COC)\[C@](CC1)([H])[C@H]2C)([C@H]3O)C([C@H]([C@@H]2O)O[C@@H](O[C@@H]4COC(C)(C)C=C)[C@@H]([C@H]([C@@H]4O)OC(C)=O)O)=C(C3)[C@H](C)COC(C)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Fusicoccin (Fusicoccin A)，一种真菌化脓毒素，14-3-3蛋白相互作用的稳定剂。Fusicoccin 使 H+-ATPase/14-3-3 复合物在植物中稳定，保持酶的激活状态。Fusicoccin 还稳定 14-3-3 蛋白与含有 C-末端 14-3-3 识别基序的结合伙伴的相互作用，如 ERα、GPIbα、TASK3、CTFR 和 p53。Fusicoccin 诱导一些癌细胞调亡，并具有抗癌活性。 |
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Ballio, A., Chain, E.B., De Leo, P., et al.Fusioccin: A new wilting toxin produced by Fusicoccum amygdali Del.Nature203(4942),297(1964)
Turner, N.C., and Grainiti, A.Fusicoccin: A fungal toxin that opens stomataNature223(5210),1070-1071(1969)
Camoni, L., Visconti, S., and Aducci, P.The phytotoxin fusicoccin, a selective stabilizer of 14-3-3 interactions?IUBMB Life65(6),513-517(2013)
Doveston, R.G., Kuusk, A., Andrei, S., et al.Small-molecule stabilization of the p53 - 14-3-3 protein-protein interactionFEBS Lett.591(16),2449-2459(2017)
Kaplan, A., Morguette, B., Kroner, A., et al.Small-molecule stabilization of 14-3-3 protein-protein interactions stimulates axon regenerationNeuron93(5),1082-1093(2017)
