Supinoxin
Cat. No.：YN270168
CAS No. ：888478-45-3
| 产品名称: | Supinoxin |
| CAS No.: | 888478-45-3 |
| Chemical Name: | 4-(3,5-dimethoxyphenyl)-N-(7-fluoro-3-methoxy-2-quinoxalinyl)-1-piperazinecarboxamide |
| Synonyms: | RX-5902 |
| 分子量: | 441.46 |
| 分子式: | C₂₂H₂₄FN₅O₄ |
| SMILES: | O=C(N1CCN(C2=CC(OC)=CC(OC)=C2)CC1)NC3=NC4=CC(F)=CC=C4N=C3OC |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Supinoxin (RX-5902) 是磷酸化 p68 RNA 解旋酶 (P-p68) 的强效口服活性抑制剂，并且是首创的抗肿瘤试剂 (anti-cancer agent)。Supinoxin 与 Y593 磷酸化的 p68 相互作用并减弱 β-catenin 的核穿梭性。 Supinoxin 诱导细胞凋亡 (apoptosis) 并抑制 TNBC 癌细胞系的生长，IC50的范围为 10 nM 至 20 nM。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Kost, G.C., Yang, M.Y., Li, L., et al.A novel anti-cancer agent, 1-(3,5-dimethoxyphenyl)-4-[(6-fluoro-2-methoxyquinoxalin-3-yl)aminocarbonyl] piperazine (RX-5902), interferes with β-catenin function through Y593 phospho-p68 RNA helicaseJ. Cell. Biochem.116(8),1595-1601(2015)
