OTS964 hydrochloride
Cat. No.：YN270173
CAS No. ：1338545-07-5
| 产品名称: | OTS964 hydrochloride |
| CAS No.: | 1338545-07-5 |
| Chemical Name: | 9-[4-[(1R)-2-(dimethylamino)-1-methylethyl]phenyl]-8-hydroxy-6-methyl-thieno[2,3-c]quinolin-4(5H)-one, monohydrochloride |
| Synonyms: | OTS964 |
| 分子量: | 428.97 |
| 分子式: | C₂₃H₂₅ClN₂O₂S |
| SMILES: | OC1=CC(C)=C2C(C3=C(SC=C3)C(N2)=O)=C1C4=CC=C([C@@H](C)CN(C)C)C=C4.Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | OTS964 hydrochloride 是一种口服有效的，高亲和力和选择性的TOPK(T 淋巴因子激活的杀伤细胞起源的蛋白激酶) 抑制剂，IC50为 28 nM。OTS964 hydrochloride 也是一种有效的细胞周期蛋白依赖激酶CDK11抑制剂，结合 CDK11B 的Kd值为 40 nM。 |
| IC50和靶点: | [{name:"TOPK:28 nM (IC50)"},{name: "CDK11B:40 nM (Kd)"}] |
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| Solvent & Solubility: |
Matsuo, Y., Park, J.H., Miyamoto, T., et al.TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesisSci. Transl. Med.6(259),259ra145(2014)
Ikeda, Y., Park, J.H., Miyamoto, T., et al.T-LAK cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in ovarian cancerClin. Cancer. Res22(24),6110-6117(2016)
