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α-NETA

Cat. No.:YN270179

  • CAS No. :31059-54-8

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    • 产品名称: α-NETA
      CAS No.: 31059-54-8
      Chemical Name: N,N,N-trimethyl-γ-oxo-2-naphthalenepropanaminium, monoiodide
      Synonyms:α-NETA
      分子量:369.24
      分子式:C₁₆H₂₀INO
      SMILES:O=C(C1=CC=C2C=CC=CC2=C1)CC[N+](C)(C)C.[I-]
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: α-NETA 是一种稳定的,非竞争性的,缓慢可逆的胆碱乙酰转移酶 (ChAT) 抑制剂,IC50为 9 μM。α-NETA 是一种有效的趋化因子样受体1 (CMKLR1) 拮抗剂。α-NETA 微弱的抑制胆碱酯酶(IC50= 84 µM)和乙酰胆碱酯(IC50= 300 µM)。α-NETA 具有抗癌活性。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Shen, X.M., Crawford, T.O., Brengman, J., et al.Functional consequences and structural interpretation of mutations of human choline acetyltransferaseHum. Mutat.32(11),1259-1267(2011)

      Mukaetova-Ladinska, E.B., Andras, A., Milne, J., et al.Synaptic proteins and choline acetyltransferase loss in visual cortex in dementia with lewy bodiesJ. Neuropathol. Exp. Neurol.72(1),53-60(2013)

      Vijayaraghavan, S., Karami, A., Aeinehband, S., et al.Regulated extracellular choline acetyltransferase activity - The plausible missing link of the distant action of acetylcholine in the cholinergic anti-inflammatory pathwayPLoS One8(6),e65936(2013)

      Sastry, B.V., Jaiswal, N., Owens, L.K., et al.2-(α-Naphthoyl)ethyltrimethylammonium iodide and its β-isomer: New selective, stable and fluorescent inhibitors of choline acetyltransferaseJ. Pharmacol. Exp. Ther.245(1),72-80(1988)

      Sastry, B.V., Jaiswal, N., Janson, V., et al.Relationships between chemical structure and inhibition of choline acetyltransferase by 2-(α-naphthoyl)ethyltrimethylammonium and related compoundsPharmacol. Res. Commun.20(9),751-771(1988)

      Eaton, B.M., and Sooranna, S.R.Regulation of the choline transport system in superfused microcarrier cultures of BeWo cellsPlacenta19(8),663-669(1998)

      Sawatzky, D.A., Kingham, P.J., Durcan, N., et al.Eosinophil-induced release of acetylcholine from differentiated cholinergic nerve cellsAm. J. Physiol. Lung Cell. Mol. Physiol.285(6),L1296-L1304(2003)

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