Illudin S
Cat. No.：YN270181
| 产品名称: | Illudin S |
| CAS No.: | 1149-99-1 |
| Chemical Name: | (2'S,3'R,6'R)-2',3'-dihydro-3',6'-dihydroxy-2'-(hydroxymethyl)-2',4',6'-trimethyl-spiro[cyclopropane-1,5'-[5H]inden]-7'(6'H)-one |
| Synonyms: | |
| 分子量: | 264.32 |
| 分子式: | C₁₅H₂₀O₄ |
| SMILES: | O=C1C2=C[C@](C)([C@@H](C2=C(C3([C@@]1(C)O)CC3)C)O)CO |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Illudin S 是一种倍半萜烯毒素，具有强抗肿瘤和抗病毒活性。Illudin S 具有基因毒性活性。 |
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Kelner, M.J., McMorris, T.C., Beck, W.T., et al.Preclinical evaluation of illudins as anticancer agentsCancer Res.47(12),3186-3189(1987)
Schobert, R., Knauer, S., Seibt, S., et al.Anticancer active illudins: Recent developments of a potent alkylating compound classCurr. Med. Chem.18,790-807(2011)
Kelner, M.J., McMorris, T.C., Estes, L., et al.Characterization of illudin S sensitivity in DNA repair-deficient Chinese hamster cells. Unusually high sensitivity of ERCC2 and ERCC3 DNA helicase-deficient mutants in comparison to other chemotherapeutic agentsBiochem. Pharmacol.48,403-409(1994)
Jaspers, N.G.J., Raams, A., Kelner, M.J., et al.Anti-tumour compounds illudin S and Irofulven induce DNA lesions ignored by global repair and exclusively processed by transcription- and replication-coupled repair pathwaysDNA Repair (Amst)1(12),1027-1038(2002)
