Ro-3306
Cat. No.：YN270183
CAS No. ：872573-93-8
| 产品名称: | Ro-3306 |
| CAS No.: | 872573-93-8 |
| Chemical Name: | 5Z-(6-quinolinylmethylene)-2-[(2-thienylmethyl)amino]-4(5H)-thiazolone |
| Synonyms: | RO3306,RO 3306 |
| 分子量: | 351.45 |
| 分子式: | C₁₈H₁₃N₃OS₂ |
| SMILES: | O=C1N=C(NCC2=CC=CS2)S/C1=C\C3=CC=C4N=CC=CC4=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Ro-3306 是一种有效，选择性的CDK1抑制剂，对 CDK1，CDK1/cyclin B1 和 CDK2/cyclin E 的Ki值为分别为 20 nM，35 nM 和 340 nM。 |
| IC50和靶点: | [{name:"CDK1:20 nM (Ki)"},{name: "CDK1/cyclinB1:35 nM (Ki)"},{name: "CDK1/cyclin A:110 nM (Ki)"},{name: "CDK2/cyclinE:340 nM (Ki)"},{name: "PKCδ:318 nM (Ki)"},{name: "SGK:497 nM (Ki)"},{name: "ERK:1980 nM (Ki)"}] |
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| Solvent & Solubility: |
Vassilev, L.T., Tovar, C., Chen, S., et al.Selective small-molecule inhibitor reveals critical mitotic functions of human CDK1Proc. Natl. Acad. Sci. USA103(28),10660-10665(2006)
Vassilev, L.T.Cell cycle synchronization at the G2/M phase border by reversible inhibition of CDK1Cell Cycle5(22),2555-2556(2006)
Kojima, K., Shimanuki, M., Shikami, M., et al.Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AMLCancer Sci.100(6),1128-1136(2009)
