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Spautin-1

Cat. No.:YN270209

  • CAS No. :1262888-28-7

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    • 参考文献
    • 产品名称: Spautin-1
      CAS No.: 1262888-28-7
      Chemical Name: 6-fluoro-N-[(4-fluorophenyl)methyl]-4-quinazolinamine
      Synonyms:Spautin 1
      分子量:271.26
      分子式:C₁₅H₁₁F₂N₃
      SMILES:FC1=CC2=C(N=CN=C2C=C1)NCC3=CC=C(F)C=C3
      存储:Please store the product under the recommended conditions in theCertificate of Analysis.
      运输:Room temperature in continental US; may vary elsewhere.
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      Purity: 98%
    • 产品描述: Spautin-1是一种特异性和有效的自噬抑制剂,可抑制泛素特异性肽酶USP10和 USP13,IC50s 约为0.6-0.7 μM。
      IC50和靶点:
      In Vitro:
      In Vivo:
      Clinical Trial:
      Solvent & Solubility:
    • Liu, J., Xia, H., Kim, M., et al.Beclin1 controls the levels of p53 by regulating the deubiquitination activity of USP10 and USP13Cell147,223-234(2011)

      Salabei, J.K., Cummins, T.D., Singh, M., et al.PDGF-mediated autophagy regulates vascular smooth muscle cell phenotype and resistance to oxidative stressBiochem. J.451(3),375-388(2013)

      Vakifahmetoglu-Norberg, H., Kim, M., Xia, H.-G., et al.Chaperone-mediated autophagy degrades mutant p53Genes Dev.27(15),1718-1730(2013)

      Mateo, R., Nagamine, C.M., Spagnolo, J., et al.Inhibition of cellular autophagy deranges dengue virion maturationJ. Virol.87(3),1312-1321(2013)

      Bouley, S.J., Maginnis, M.S., Derdowski, A., et al.Host cell autophagy promotes BK virus infectionVirology456-457,87-95(2014)

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