SR-4835
Cat. No.：YN270211
CAS No. ：2387704-62-1
| 产品名称: | SR-4835 |
| CAS No.: | 2387704-62-1 |
| Chemical Name: | |
| Synonyms: | SR4835,SR 4835 |
| 分子量: | 499.36 |
| 分子式: | C₂₁H₂₀Cl₂N₁₀O |
| SMILES: | CN1N=CC(N2C3=NC(N4CCOCC4)=NC(NCC5=NC6=C(N5)C=C(Cl)C(Cl)=C6)=C3N=C2)=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SR-4835 是有效，高选择性和 ATP 竞争性的CDK12/CDK13双重抑制剂 (CDK12：IC50=99 nM，Kd=98 nM；CDK13：Kd=4.9 nM)。SR-4835 与破坏 DNA 的化学疗法和 PARP 抑制剂协同作用，并引起三阴性乳腺癌 (TNBC) 细胞凋亡。 |
| IC50和靶点: | [{name:"CDK12:99 nM (IC50)"},{name: "CDK12:98 nM (Kd)"},{name: "CDK13:4.9 nM (Kd)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
