AR-42
Cat. No.：YN270218
| 产品名称: | AR-42 |
| CAS No.: | 935881-37-1 |
| Chemical Name: | (αS)-N-[4-[(Hydroxyamino)carbonyl]phenyl]-α-(1-methylethyl)benzeneacetamide; (S)-(+)-N-Hydroxy-4-(3-methyl-2-phenyl-butyrylamino)-benzamide; (S)-HDAC 42; OSU-HDAC 42 |
| Synonyms: | HDAC-42; OSU-HDAC42 |
| 分子量: | 312.36 |
| 分子式: | C₁₈H₂₀N₂O₃ |
| SMILES: | CC([C@@H](C1=CC=CC=C1)C(NC2=CC=C(C=C2)C(NO)=O)=O)C |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | AR-42 (HDAC-42) 是一种口服生物有效的泛HDAC抑制剂 (IC50=16 nM)。AR-42 (HDAC-42) 诱导生长抑制、细胞周期阻滞、凋亡和 caspases-3/7 活化。AR-42 (HDAC-42) 促进 H3、H4 和 α-微管蛋白的高乙酰化，并上调 p21。AR-42 (HDAC-42) 对多种人肿瘤细胞具有细胞毒性。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Bai, L.Y., et al.: Oral. Oncol., 47, 1127 (2011)
Huang, P.H., et al.: Molec. Cellular. Pharmacol., 3, 39 (2011)
