Tubastatin A
Cat. No.：YN270221
CAS No. ：1252003-15-8
| 产品名称: | Tubastatin A |
| CAS No.: | 1252003-15-8 |
| Chemical Name: | N-hydroxy-4-[(1,2,3,4-tetrahydro-2-methyl-5H-pyrido[4,3-b]indol-5-yl)methyl]-benzamide |
| Synonyms: | Tubastatin A BASE |
| 分子量: | 335.40 |
| 分子式: | C₂₀H₂₁N₃O₂ |
| SMILES: | O=C(NO)C1=CC=C(CN2C3=C(CN(C)CC3)C4=C2C=CC=C4)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Tubastatin A 是一种有效的，选择性的HDAC6抑制剂，IC50值为 15 nM，对其选择性是对 HDAC8 的 57 倍多，是其他同工酶的 1000 多倍。 |
| IC50和靶点: | [{name:"HDAC6:15 nM (IC50)"},{name: "HDAC8:854 nM (IC50)"},{name: "HDAC1:16400 nM (IC50)"}] |
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| Solvent & Solubility: |
Butler, K.V., Kalin, J., Brochier, C., et al.Rational design and simple chemistry yield a superior, neuroprotective HDAC6 inhibitor, Tubastatin AJ. Am. Chem. Soc.132(31),10842-10846(2010)
