PHA-767491 hydrochloride
Cat. No.：YN270230
CAS No. ：942425-68-5
| 产品名称: | PHA-767491 hydrochloride |
| CAS No.: | 942425-68-5 |
| Chemical Name: | 1,5,6,7-tetrahydro-2-(4-pyridinyl)-4H-pyrrolo[3,2-c]pyridin-4-one, monohydrochloride |
| Synonyms: | CAY-10572 hydrochloride |
| 分子量: | 249.70 |
| 分子式: | C₁₂H₁₂ClN₃O |
| SMILES: | O=C1C2=C(NC(C3=CC=NC=C3)=C2)CCN1.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PHA-767491 hydrochloride 是一种Cdc7-Dbf4 (DDK)/Cdk9的双重抑制剂，IC50值分别为 10 nM 和 34 nM。 |
| IC50和靶点: | [{name:"CDK9:34 nM (IC50)"},{name: "CDK2:240 nM (IC50)"},{name: "CDK1:250 nM (IC50)"},{name: "CDK5:460 nM (IC50)"},{name: "GSK3-β:220 nM (IC50)"},{name: "Mk2:470 nM (IC50)"},{name: "Plk1:980 nM (IC50)"},{name: "Chk2:1100 nM (IC50)"}] |
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Montagnoli, A., Valsasina, B., Croci, V., et al.A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activityNat. Chem. Biol.4(6),357-365(2008)
Menichincheri, M., Bargiotti, A., Berthelsen, J., et al.First Cdc7 kinase inhibitors: Pyrrolopyridinones as potent and orally active antitumor agents. 2. lead discoveryJ. Med. Chem.52(2),293-307(2009)
