Epothilone A
Cat. No.：YN270231
| 产品名称: | Epothilone A |
| CAS No.: | 152044-53-6 |
| Chemical Name: | (1S,16R)-7S,11S-dihydroxy-8,8,10R,12S-tetramethyl-3S-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione |
| Synonyms: | Epo A |
| 分子量: | 493.66 |
| 分子式: | C₂₆H₃₉NO₆S |
| SMILES: | O=C(C[C@H](O)C1(C)C)O[C@H](/C(C)=C/C2=CSC(C)=N2)C[C@]3([H])O[C@]3([H])CCC[C@H](C)[C@H](O)[C@@H](C)C1=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Epothilone A 是紫杉醇和管蛋白(tubulin)聚合物结合的竞争性抑制剂，其Ki值为 0.6-1.4 μM。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Cheng, K.L., Bradley, T., and Budman, D.R.Novel microtubule-targeting agents - the epothilonesBiologics2(4),789-811(2008)
Bollag, D.M., McQueney, P.A., Zhu, J., et al.Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of actionCancer Res.55(11),2325-2333(1995)
Goodin, S., Kane, M.P., and Rubin, E.H.Epothilones: Mechanism of action and biologic activityJ. Clin. Oncol.22(10),2015-2025(2011)
Kowalski, R.J., Giannakakou, P., and Hamel, E.Activities of the microtubule-stabilizing agents epothilones A and B with purified tubulin and in cells resistant to paclitaxel (Taxol(R))J. Biol. Chem.272(4),2534-2541(1997)
