Piclidenoson
Cat. No.：YN270241
CAS No. ：152918-18-8
| 产品名称: | Piclidenoson |
| CAS No.: | 152918-18-8 |
| Chemical Name: | 1-deoxy-1-[6-[[(3-iodophenyl)methyl]amino]-9H-purin-9-yl]-N-methyl-β-D-ribofuranuronamide |
| Synonyms: | IB-MECA; CF-101 |
| 分子量: | 510.29 |
| 分子式: | C₁₈H₁₉IN₆O₄ |
| SMILES: | O[C@H]1[C@H](N2C=NC3=C(NCC4=CC=CC(I)=C4)N=CN=C23)O[C@H](C(NC)=O)[C@H]1O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Piclidenoson (IB-MECA;CF-101) 是一种首创的，具有口服活性的，选择性的腺苷 A3 受体 (A3AR) 激动剂。Piclidenoson 在不同类型的癌细胞如黑色素瘤、白血病中表现出抗增殖和诱导凋亡 (apoptosis) 的作用。Piclidenoson 可用于自身免疫性炎症疾病和 COVID-19 的研究。 |
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Jacobson, K.A., Merighi, S., Varani, K., et al.A3 adenosine receptors as modulators of inflammation: From medicinal chemistry to therapyMed. Res. Rev.38(4),1031-1072(2018)
Auchampach, J.A., Rizvi, A., Qiu, Y., et al.Selective activation of A3 adenosine receptors with N6-(3-iodobenzyl)adenosine-5′-N-methyluronamide protects against myocardial stunning and infarction without hemodynamic changes in conscious rabbitsCirc. Res.80(6),800-809(1997)
Mabley, J., Soriano, F., Pacher, P., et al.The adenosine A3 receptor agonist, N6-(3-iodobenzyl)-adenosine-5'-N-methyluronamide, is protective in two murine models of colitisEur. J. Pharmacol.466(3),323-329(2003)
