Estramustine phosphate sodium
Cat. No.：YN270247
CAS No. ：52205-73-9
| 产品名称: | Estramustine phosphate sodium |
| CAS No.: | 52205-73-9 |
| Chemical Name: | estra-1,3,5(10)-triene-3,17-diol (17β)-3-[N,N-bis(2-chloroethyl)carbamate] 17-(dihydrogen phosphate), disodium salt |
| Synonyms: | 雌莫司汀磷酸钠 |
| 分子量: | 564.35 |
| 分子式: | C₂₃H₃₀Cl₂NNa₂O₆P |
| SMILES: | O=C(N(CCCl)CCCl)OC1=CC2=C(C=C1)[C@@]3([H])CC[C@@]4(C)[C@](CC[C@@H]4OP(O[Na])(O[Na])=O)([H])[C@]3([H])CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Estramustine phosphate sodium，一种雌二醇类似物，是一种具有口服活性抗微管化疗剂。Estramustine phosphate sodium 通过与微管相关蛋白 (MAP) 和/或微管蛋白结合而使微管解聚。Estramustine phosphate sodium 可诱导前列腺癌细胞凋亡 (apoptosis)，并可用于前列腺癌的研究。 |
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Tew, K.D., and Stearns, M.E.Estramustine--a nitrogen mustard/steroid with antimicrotubule activityPharmacol. Ther.43(3),299-319(1989)
Hartley-Asp, B.Estramustine-induced mitotic arrest in two human prostatic carcinoma cell lines DU 145 and PC-3Prostate5(1),93-100(1984)
Yoshida, D., Hoshino, S., Shimura, T., et al.Drug-induced apoptosis by anti-microtubule agent, estramustine phosphate on human malignant glioma cell line, U87MG; in vitro studyJ. Neurooncol.47(2),133-140(2000)
Wang, L.G., Liu, X.M., Kreis, W., et al.Androgen antagonistic effect of estramustine phosphate (EMP) metabolites on wild-type and mutated androgen receptorBiochem. Pharmacol.55(9),1427-1433(1998)
