Nelarabine
Cat. No.：YN270260
CAS No. ：121032-29-9
| 产品名称: | Nelarabine |
| CAS No.: | 121032-29-9 |
| Chemical Name: | 9-β-D-arabinofuranosyl-6-methoxy-9H-purin-2-amine |
| Synonyms: | 奈拉滨; 506U78; GW 506U78; Nelzarabine |
| 分子量: | 297.27 |
| 分子式: | C₁₁H₁₅N₅O₅ |
| SMILES: | NC1=NC(OC)=C2N=CN([C@H]3[C@H]([C@@H]([C@@H](CO)O3)O)O)C2=N1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nelarabine (Arranon, 506U78)是嘌呤核苷酸类似物，为DNA合成抑制剂，对肿瘤细胞的IC50为0.067-2.15 μM，可作用于T细胞急性淋巴细胞白血病。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Robak, T., Korycka, A., Lech-Maranda, E., et al.Current status of older and new purine nucleoside analogues in the treatment of lymphoproliferative diseasesMolecules14(3),1183-1226(2009)
Rodriguez, C.O., Jr., Mitchell, B.S., Ayres, M., et al.Arabinosylguanine is phosphorylated by both cytoplasmic deoxycytidine kinase and mitochondrial deoxyguanosine kinaseCancer Res.62(11),3100-3105(2002)
Rodriguez, C.O., Jr., Stellrecht, C.M., and Gandhi, V.Mechanisms for T-cell selective cytotoxicity of arabinosylguanineBlood102(5),1842-1848(2003)
