Nimustine hydrochloride
Cat. No.：YN270261
CAS No. ：55661-38-6
| 产品名称: | Nimustine hydrochloride |
| CAS No.: | 55661-38-6 |
| Chemical Name: | N′-[(4-amino-2-methyl-5-pyrimidinyl)methyl]-N-(2-chloroethyl)-N-nitroso-urea, monohydrochloride |
| Synonyms: | ACNU |
| 分子量: | 309.15 |
| 分子式: | C₉H₁₄Cl₂N₆O₂ |
| SMILES: | O=C(NCC1=CN=C(C)N=C1N)N(CCCl)N=O.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | Nimustine hydrochloride (ACNU) 是一种 DNA 交联剂和 DNA 烷基化剂，能诱导 DNA 复制损伤和 DNA 双链断裂，抑制DNA合成，常用于胶质母细胞瘤的化疗中。 |
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Heal, J.M., Fox, P.L., and Schein, P.S.A structure-activity study of seven new water soluble nitrosoureasBiochem. Pharmacol.28(8),1301-1306(1978)
Yoshida, J., Shibuya, N., Kobayashi, T., et al.Sensitivity to I-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2- chioroethyl)-3-nitrosourea hydrochloride (ACNU) of glioma cells in vivo and in vitroCancer50(3),410-418(1982)
Hasegawa, H., Shapiro, W.R., and Posner, J.B.Chemotherapy of experimental metastatic brain tumors in female Wistar ratsCancer Res.39(7 Pt 1),2691-2697(1979)
