MK-8745
Cat. No.：YN270268
CAS No. ：885325-71-3
| 产品名称: | MK-8745 |
| CAS No.: | 885325-71-3 |
| Chemical Name: | (3-chloro-2-fluorophenyl)[4-[[6-(2-thiazolylamino)-2-pyridinyl]methyl]-1-piperazinyl]-methanone |
| Synonyms: | |
| 分子量: | 431.91 |
| 分子式: | C₂₀H₁₉ClFN₅OS |
| SMILES: | O=C(C1=CC=CC(Cl)=C1F)N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | MK-8745是极光激酶抑制剂 (aurora A)，IC50值为0.6 nM。 |
| IC50和靶点: | [{name:"Aurora A:0.6 nM (IC50)"}] |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Nair, J.S., Ho, A.L., and Schwartz, G.K.The induction of polyploidy or apoptosis by the Aurora A kinase inhibitor MK8745 is p53-dependentCell Cycle11(4),807-817(2012)
Chowdhury, A., Chowdhury, S., and Tsai, M.Y.A novel Aurora kinase A inhibitor MK-8745 predicts TPX2 as a therapeutic biomarker in non-Hodgkin lymphoma cell linesLeuk. Lymphoma53(3),462-471(2012)
