C646
Cat. No.：YN270270
| 产品名称: | C646 |
| CAS No.: | 328968-36-1 |
| Chemical Name: | 4-[4-[[5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl]methylene]-4,5-dihydro-3-methyl-5-oxo-1H-pyra-zol-1-yl]-benzoic acid |
| Synonyms: | C 646;C646 C-646 C 646;4-(4-((5-(4,5-Dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzoic acid;C-646;(Z)-4-(4-((5-(4,5-dimethyl-2-nitrophenyl)furan-2-yl)methylene)-3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)ben |
| 分子量: | 445.42 |
| 分子式: | C₂₄H₁₉N₃O₆ |
| SMILES: | O=C(O)C1=CC=C(N2N=C(C)/C(C2=O)=C\C3=CC=C(C4=CC(C)=C(C)C=C4[N+]([O-])=O)O3)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | C646 是一种竞争性的选择性histone acetyltransferase p300抑制剂，Ki值为 400 nM，对其他的乙酰转移酶作用较小。 |
| IC50和靶点: | |
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Bowers, E.M., Yan, G., Mukherjee, C., et al.Virtual ligand screening of the p300/CBP histone acetyltransferase: Identification of a selective small molecule inhibitorChem. Biol.17(5),471-482(2010)
Gao, X.n., Lin, J., Ning, Q.y., et al.A histone acetyltransferase p300 inhibitor C646 induces cell cycle arrest and apoptosis selectively in AML1-ETO-positive AML cellsPLoS One8(2),(2013)
Santer, F.R., Höschele, P.P.S., Oh, S.J., et al.Inhibition of the acetyltransferases p300 and CBP reveals a targetable function for p300 in the survival and invasion pathways of prostate cancer cell linesMol. Cancer Ther.10(9),1644-1655(2011)
Marek, R., Coelho, C.M., Sullivan, R.K.P., et al.Paradoxical enhancement of fear extinction memory and synaptic plasticity by inhibition of the histone acetyltransferase p300J. Neurosci.31(20),7486-7491(2011)
Crump, N.T., Hazzalin, C.A., Bowers, E.M., et al.Dynamic acetylation of all lysine-4 trimethylated histone H3 is evolutionarily conserved and mediated by p300/CBPProc. Natl. Acad. Sci. USA108(19),7814-7819(2011)
