NVP 231
Cat. No.：YN270274
CAS No. ：362003-83-6
| 产品名称: | NVP 231 |
| CAS No.: | 362003-83-6 |
| Chemical Name: | N-[2-(benzoylamino)-6-benzothiazolyl]-tricyclo[3.3.1.13,7]decane-1-carboxamide |
| Synonyms: | NVP-231,NVP 231，NVP231 |
| 分子量: | 431.55 |
| 分子式: | C₂₅H₂₅N₃O₂S |
| SMILES: | O=C(C1(C[C@@H](C2)C3)C[C@@H]3C[C@@H]2C1)NC4=CC=C5N=C(NC(C6=CC=CC=C6)=O)SC5=C4 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | NVP 231 是一种强效、特异、可逆的神经酰胺激酶 (CerK) 抑制剂 (IC50=12 nM)，可竞争性地抑制神经酰胺与 CerK 的结合。NVP 231 通过增加 DNA 片段和 caspase-3 和 caspase-9 的裂解来诱导细胞凋亡 (apoptosis)。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Graf, C., Klumpp, M., Habig, M., et al.Targeting ceramide metabolism with a potent and specific ceramide kinase inhibitorMol. Pharm.74(4),925-932(2008)
Niwa, S., Graf, C., and Bornancin, F.Ceramide kinase deficiency impairs microendothelial cell angiogenesis in vitroMicrovasc. Res.77(3),389-393(2009)
