GSK1324726A
Cat. No.：YN270279
CAS No. ：1300031-52-0
| 产品名称: | GSK1324726A |
| CAS No.: | 1300031-52-0 |
| Chemical Name: | 4-[(2S,4R)-1-acetyl-4-[(4-chlorophenyl)amino]-1,2,3,4-tetrahydro-2-methyl-6-quinolinyl]-benzoic acid |
| Synonyms: | I-BET726 |
| 分子量: | 434.91 |
| 分子式: | C₂₅H₂₃ClN₂O₃ |
| SMILES: | ClC1=CC=C(N[C@H]2C3=C(C=CC(C4=CC=C(C(O)=O)C=C4)=C3)N(C(C)=O)[C@@H](C)C2)C=C1 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | GSK1324726A 是一种有效的选择性BET蛋白抑制剂，高亲和力结合到BRD2(IC50=41 nM)，BRD3(IC50=31 nM) 和BRD4(IC50=22 nM)。 |
| IC50和靶点: | |
| In Vitro: | |
| In Vivo: | |
| Clinical Trial: | |
| Solvent & Solubility: |
Gosmini, R., Nguyen, V.L., Toum, J., et al.The discovery of I-BET726 (GSK1324726A), a potent tetrahydroquinoline apoA1 up-regulator and selective BET bromodomain inhibitorJ. Med. Chem.57,8111-8131(2014)
Wyce, A., Ganji, G., Smitheman, K.N., et al.BET inhibition silences expression of MYCN and BCL2 and induces cytotoxicity in neuroblastoma tumor modelsPLoS One8(8),e72967(2013)
