SGI-1027
Cat. No.：YN270280
| 产品名称: | SGI-1027 |
| CAS No.: | 1020149-73-8 |
| Chemical Name: | N-[4-[(2-amino-6-methyl-4-pyrimidinyl)amino]phenyl]-4-(4-quinolinylamino)-benzamide |
| Synonyms: | DNA Methyltransferase Inhibitor II |
| 分子量: | 461.52 |
| 分子式: | C₂₇H₂₃N₇O |
| SMILES: | O=C(NC1=CC=C(NC2=NC(N)=NC(C)=C2)C=C1)C3=CC=C(NC4=CC=NC5=CC=CC=C45)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SGI-1027 是 DNA 甲基转移酶 (DNMT) 抑制剂，对以 poly(dI-dC) 为底物的 DNMT3B，DNMT3A 和 DNMT1 的IC50值分别为 7.5 μM，8 μM 和 12.5 μM。 |
| IC50和靶点: | [{name:"DNMT3B:7.5 μM (IC50)"},{name: "DNMT3A:8 μM (IC50)"},{name: "DNMT1:12.5 μM (IC50)"}] |
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| Solvent & Solubility: |
Datta, J., Ghoshal, K., Denny, W.A., et al.A new class of quinoline-based DNA hypomethylating agents reactivates tumor suppressor genes by blocking DNA methyltransferase 1 activity and inducing its degredationCancer Res.69(10),4277-4285(2009)
