b-AP15
Cat. No.：YN270281
CAS No. ：1009817-63-3
| 产品名称: | b-AP15 |
| CAS No.: | 1009817-63-3 |
| Chemical Name: | 3E,5E-bis[(4-nitrophenyl)methylene]-1-(1-oxo-2-propen-1-yl)-4-piperidinone |
| Synonyms: | NSC 687852 |
| 分子量: | 419.39 |
| 分子式: | C₂₂H₁₇N₃O₆ |
| SMILES: | O=C1/C(CN(C(C=C)=O)C/C1=C\C2=CC=C([N+]([O-])=O)C=C2)=C/C3=CC=C([N+]([O-])=O)C=C3 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | b-AP15 特异性抑制去泛素化酶 (deubiquitinating)UCHL5和Usp14活性。 |
| IC50和靶点: | |
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| Solvent & Solubility: |
Zhang, W., and Sidhu, S.S.Development of inhibitors in the ubiquitination cascadeFEBS Lett.588(2),356-367(2014)
D'Arcy, P., Brnjic, S., Olofsson, M.H., et al.Inhibition of proteasome deubiquitinating activity as a new cancer therapyNat. Med.17(12),1636-1640(2011)
Tian, Z., D'Arcy, P., Wang, X., et al.A novel small molecule inhibitor of deubiquitylating enzyme USP14 and UCHL5 induces apoptosis in multiple myeloma and overcomes bortezomib resistanceBlood123(5),706-716(2014)
Sarhan, D., Wennerberg, E., D'Arcy, P., et al.A novel inhibitor of proteasome deubiquitinating activity renders tumor cells sensitive to TRAIL-mediated apoptosis by natural killer cells and T cellsCancer Immunol. Immunother.62(8),1359-1368(2013)
