(S)-Thalidomide
Cat. No.：YN270289
CAS No. ：841-67-8
| 产品名称: | (S)-Thalidomide |
| CAS No.: | 841-67-8 |
| Chemical Name: | 2-[(3S)-2,6-dioxo-3-piperidinyl]-1H-isoindole-1,3(2H)-dione |
| Synonyms: | (S)-(-)-Thalidomide |
| 分子量: | 258.23 |
| 分子式: | C₁₃H₁₀N₂O₄ |
| SMILES: | O=C1N([C@@H](CC2)C(NC2=O)=O)C(C3=C1C=CC=C3)=O |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | (S)-Thalidomide ((S)-(-)-Thalidomide) 是 Thalidomide 的 S-对映体。(S)-Thalidomide 具有免疫调节，抗炎，抗血管生成和促凋亡作用。(S)-Thalidomide 通过与 cereblon (CRBN) 结合诱导致畸作用。 |
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| Solvent & Solubility: |
Nishimura, K., Hashimoto, Y., and Iwasaki, S.(S)-form of α -methyl-N( α )-phthalimidoglutarimide, but not its (R)-form, enhanced phorbol ester-induced tumor necrosis factor-α production by human leukemia cell HL-60: Implication of optical resolution of thalidomidal effectsChem. Pharm. Bull. (Tokyo)42(5),1157-1159(1994)
Field, E.O., Gibbs, J.E., Tucker, D.F., et al.Effect of thalidomide on the graft versus host reactionNature211(5055),1308-1310(1966)
Fabro, S., Smith, R.L., and Williams, R.T.Toxicity and teratogenicity of optical isomers of thalidomideNature215(5098),296(1967)
