SBE13 Hydrochloride
Cat. No.：YN270297
| 产品名称: | SBE13 Hydrochloride |
| CAS No.: | 1052532-15-6 |
| Chemical Name: | N-[[4-[(6-chloro-3-pyridinyl)methoxy]-3-methoxyphenyl]methyl]-3,4-dimethoxy-benzeneethanamine, monohydrochloride |
| Synonyms: | SBE 13 HCl,SBE 13 hydrochloride |
| 分子量: | 479.40 |
| 分子式: | C₂₄H₂₈Cl₂N₂O₄ |
| SMILES: | COC1=CC=C(CCNCC2=CC=C(OCC3=CC=C(Cl)N=C3)C(OC)=C2)C=C1OC.[H]Cl |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | SBE13 Hydrochloride 是一种有效的，选择性的Plk1抑制剂，IC50值为 200 pM，对 Plk2 (IC50>66 μM) 或 Plk3 (IC50=875 nM) 的作用较弱。 |
| IC50和靶点: | [{name:"PLK1:200 pM (IC50)"},{name: "PLK3:875 nM (IC50)"}] |
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Keppner, S., Proschak, E., Schneider, G., et al.Identification and validation of a potent type II inhibitor of inactive polo-like kinase 1Chem. Med. Chem.4(11),1806-1809(2009)
Keppner, S., Proschak, E., Kaufmann, M.T., et al.Biological impact of freezing Plk1 in its inactive conformation in cancer cellsCell Cycle9(4),761-773(2010)
Keppner, S., Proschak, E., Schneider, A., et al.Fate of primary cells at the G1/S boundary after polo-like kinase 1 inhibition by SBE13Cell Cycle10(4),708-720(2011)
