PCI-34051
Cat. No.：YN270301
CAS No. ：950762-95-5
| 产品名称: | PCI-34051 |
| CAS No.: | 950762-95-5 |
| Chemical Name: | N-hydroxy-1-[(4-methoxyphenyl)methyl]-1H-indole-6-carboxamide |
| Synonyms: | N-羟基-1-(4-甲氧基苄基)-1H-吲哚-6-甲酰胺,PCI 34051 |
| 分子量: | 296.32 |
| 分子式: | C₁₇H₁₆N₂O₃ |
| SMILES: | COC(C=C1)=CC=C1CN2C3=CC(C(NO)=O)=CC=C3C=C2 |
| 存储: | Please store the product under the recommended conditions in theCertificate of Analysis. |
| 运输: | Room temperature in continental US; may vary elsewhere. |
| 产品描述: | PCI-34051 是一种有效的选择性的HDAC8抑制剂，IC50为 10 nM。 |
| IC50和靶点: | [{name:"HDAC8:10 nM (IC50)"},{name: "HDAC6:2.9 μM (IC50)"},{name: "HDAC1:4 μM (IC50)"},{name: "HDAC10:13 μM (IC50)"}] |
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Balasubramanian, S., Ramos, J., Luo, W., et al.A novel histone deacetylase 8 (HDAC8)-specific inhibitor PCI-34051 induces apoptosis in T-cell lymphomasLeukemia22(5),1026-1034(2008)
Deardorff, M.A., Bando, M., Nakato, R., et al.HDAC8 mutations in Cornelia de Lange syndrome affect the cohesin acetylation cycleNature489(7415),313-317(2012)
